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当然，风险亦不容忽视。Infigratinib是泛FGFR1-4抑制剂，对FGFR1等的抑制可能引起高磷血症等副作用。3期试验中约有4%患者出现轻度、短暂的高磷血症。在儿科长期用药的背景下，其安全性仍需更严格的监测，监管的要求也会更严格。
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This time, before we perturb the input image, we take the value given by the threshold matrix and divide it by , where is the number of levels for each colour component. As a result, each pixel is perturbed just enough to cover the minimal distance between two colours in the palette. Since the entire palette is evenly distributed across colour space, we only need to modify the range of perturbation along each axis. The dithering equation then becomes:
What's on deck: Apple's rumored 2026 MacBook lineupBased on its usual update cycle, Apple's 2026 launches will almost certainly include new MacBook Airs in 13- and 15-inch sizes and new MacBook Pros in 14- and 16-inch variants. The Airs will likely come with the base M5 chip (the same one found in the existing 14-inch MacBook Pro), while the new Pros will probably be powered by high-end M5 Pro and M5 Max chips.